This commentary discusses the evolutionary adaptation of SARS-CoV-2 to its human host. The authors suggest that while the earliest mutations likely did not alter viral fitness , subsequent mutations may have increased the overall mutation rate, generating more diverse viral clades. The emergence of new mutation patterns, coinciding with a decline in fatality rates, suggests a "converged evolution" as the virus adapts. This process may lead to a loss of virulence as SARS-CoV-2 moves toward becoming endemic, allowing it to spread without high mortality.